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FOX proteins represent a large family of transcription factors, of which FOXOs FOXO1, FOXO3, FOXO4 and FOXO6 are the most well-characterised regulators of downstream insulin signalling Here, the effect of insulin is one of negative regulation Fig 2a Upon insulin stimulation, FOXOs undergo multisite phosphorylation by Akt and or SGK kinase.
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It is an autoimmune reaction that attacks cells in your pancreas that produce insulin and is caused by inherited genetics or environmental elements.
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We should aim to eat 3-4 meals daily, with the largest being at breakfast, and the smallest at dinner Traditional methods of treating diabetes depend on what type of diabetes you have.
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